Lung Cancer Metastasis: Novel Biological Mechanisms and Impact on Clinical Practice

!: Promotional Lung Cancer Metastasis: Novel Biological Mechanisms and Impact on Clinical Practice Review

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Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

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Economic Analyses at EPA: Assessing Regulatory Impact (Resources for the Future)

!1: Now is the time Economic Analyses at EPA: Assessing Regulatory Impact (Resources for the Future) Order Today!

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"Lucid, informative, readable. It goes behind the numbers to give readers insight into what works and what doesn't -- and why -- in using economic analysis to improve environmental decision making." -- William K. Reilly, former administrator, U.S. Environmental Protection Agency

For years, the Environmental Protection Agency has been conducting programmatic "economic analyses," also known as Regulatory Impact Analyses (RIAs), to assess the economic effects of its regulatory efforts. This important new volume explains the purpose of these analyses, along with their design, execution, conclusions, and their ultimate impact on environmental rules. Morgenstern, formerly director of EPA's Office of Policy Analysis, has assembled twelve original case studies of RIAs performed over the past decade. The contributors, most of whom actually worked on these RIAs, provide detailed examination of why and how they were performed. They critique the nature, amount, and quality of data used by the EPA in their benefit-cost and cost-effectiveness analyses as well as the subsequent utilization of that data in decisionmaking. The authors illustrate how the analyses take into account difficult issues such as discounting, risk, nonmonetized benefits and costs, and equity.

Morgenstern provides historical context and the legal framework for requiring and conducting EAs, including the basic procedure outlined by the Clinton administration in 1996. He synthesizes the studies into thoughtful general conclusions, drawing important lessons that will improve future analyses.

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9/11 Impact On Mesothelioma: Researchers Worry

Researchers and experts are concerned about the possible impact of the 9/11 disaster on mesothelioma in the coming years and decades.

It is generally agreed that the large amounts of asbestos released during the 9/11 disaster will have a substantial impact on the number of new mesothelioma Cases in the United States in years to come.

9/11 concerns over new mesothelioma Cases are further complicated by the fact that it usually takes 20 to 40 years after asbestos exposure for mesothelioma cases to start developing. Currently there are about 3,500 mesothelioma cases being treated annually in the country.

And even where mesothelioma does occur, it is not known exactly how many of these patients will be actually treated because there is usually a large number who are misdiagnosed as having metastatic adenocarcinoma which is another different form of cancer. This could further worsen the impact of 9/11 on new mesothelioma cases over the next couple of decades.

Then there are the usual problems that hinder treatment of mesothelioma like the medical community not bothering to refer patients to centers where potentially curative treatment can be given because it is generally believed that the disease has no known cure. The truth is that although mesothelioma experts are far from having a cure for all patients, recent developments of more effective treatments including radical surgery and advanced radiotherapeutic modalities now offer much better odds for longer survival to patients suffering from mesothelioma.

Before 9/11, researchers had expected the number of new mesothelioma cases to peak in the next few years and probably begin to fall. More so because of the major asbestos control initiatives of the 1970s.

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