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Pancreatic Cancer Causes, Diagnosis, Treatment and Prognosis

Pancreatic cancer begins in the tissues of your pancreas, a large organ that lies horizontally behind the lower part of the stomach. Pancreatic cancer occurs most commonly in men between the ages of 35 and 70, it is the fourth most common cause of cancer mortality (behind lung cancer, colorectal cancer and breast cancer). Pancreatic carcinoma is usually an adenocarcinoma and it usually arises from the pancreatic duct cells which make up the major part of the pancreas.

Cause of pancreatic cancer
Pancreatic tumors are caused by damage to genes, but it is not known exactly why this damage happens. Evidence suggests that it is linked to exposure to carcinogens such as; cigarettes, food high in fat and protein and food additives. Possible predisposing factors are chronic pancreatitis, diabetes mellitus and chronic alcohol abuse.

There is some evidence that people who don't eat many fresh vegetables and fruits are more at risk from pancreatic cancer.also being overweight may cause a small increase in the risk. Some industrial chemicals called chlorinated hydrocarbon solvents have been linked to pancreatic cancer, although they are unlikely to be a major factor. Other chemicals and exposures that have been linked to an increased risk of pancreatic carcinoma in some studies include pesticides, radiation, nickel, chromium and iron.

The average age of onset of pancreatic cancer is between 70 to 80 but heavy smokers and heavy drinkers present an average of seven to 10 years earlier than the rest of the population.

Signs and symptoms of pancreatic cancer
The most common are weight loss, abdominal or low back pain, jaundice and diarrhea.
Other more general effects include; fever, skin lesions, depression, anxiety and a premonition of impending death. Ascites ( fluid retention in the abdomen ) can be a sign of pancreatic tumors.

Diagnosis
It is very difficult to diagnose pancreatic cancer as the pancreas is so deep within the body and symptoms vary depending on the exact location of the tumor in the pancreas and which cells or function of the pancreas is affected by the tumour or cancer. Unfortunately the symptoms of this cancer can also be quite vague and non specific and may be caused by many other more common and less serious conditions.

Pancreatic cancer typically spreads rapidly and is seldom detected in its early stages, which is a major reason why it is a leading cause of cancer death. Specialists believe that anyone over 50 who develops diabetes and has unexplained weight loss should be investigated for other pancreatic disease. Courvoisier sign defines the presence of jaundice and a painlessly distended gallbladder as strongly indicative of pancreatic cancer and may be used to distinguish pancreatic cancer from gallstones.

Treatment
Treatment for pancreatic cancer depends on the stage and location of the cancer as well as on your age, overall health and personal preferences. The first goal of treatment is to eliminate the cancer, when possible. When that isn't an option, the focus may be on preventing the pancreatic cancer from growing or causing more harm. This cancer is relatively resistant to medical treatment and the only potentially curative treatment is surgery. Radiation therapy for pancreatic cancer can palliate pain but does not affect the patients survival.

Gemcitabine was approved by the US FDA in 1998 after a clinical trial reported improvements in quality of life in patients with advanced pancreatic cancer. Management of pain and other symptoms is an important part of the treatment of advanced cancer.

Prognosis
Pancreatic cancer often has a poor prognosis, even when diagnosed early and the median survival period from the time of diagnosis until demise is arguably the worst of any of the cancers. The best predictors of long term survival after surgery are a tumor diameter of less than 3 cm, no nodal involvement, negative resection margins, and diploid tumor DNA content.

Due to difficulties in diagnosis, the aggressive nature of pancreatic cancer and the limited systemic treatments available, the five-year survival rate for patients who have pancreatic adenocarcinoma is only about 5%. For cancer that cannot be removed completely with surgery, or cancer that has spread beyond the pancreas, cure is not currently possible and the average survival is usually less than 1 year.

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Low Price The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and Government Neglect

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One of the basis for reading is to read a book in good condition.

Thanks to all those who sell and share their books.

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Lowest Price The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and Government Neglect

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A powerful book, page-turning read and extremely well-organized for nonscientists - well-balanced, reminded us all to be aware of what goes into our bodies and to educate ourselves about our own health care choices. As a parent, I now wonder what our children received in their vaccines in the 1980s and 90s that I so blithely took them to receive.

After reading of one more example of our government's collusion with the pharmacentical industry as well as our government's inability to adapt to changing medical research, I am hopeless about our ability to prepare for the possible flu pandemic or any kind of biochemical warfare that may be in our future.

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Best Prices The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and Government Neglect

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I was involved in the defense of President Clinton during his impeachment proceedings. The hearings that the Judiciary held during those proceedings left me with a cynical attitude towards our government, but the impeachment proceedings did not shock me as much as the story this book tells about our government giving a contaminated vaccine to millions of children, knowing that it had a monkey virus that had caused cancer in laboratory animals. Worse yet, the medical leaders in our government repressed research showing that this virus could cause cancer in humans. I highly recommend reading this book to find out what they did to the millions of people who were given that vaccine.

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Economic Analyses at EPA: Assessing Regulatory Impact (Resources for the Future)

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"Lucid, informative, readable. It goes behind the numbers to give readers insight into what works and what doesn't -- and why -- in using economic analysis to improve environmental decision making." -- William K. Reilly, former administrator, U.S. Environmental Protection Agency

For years, the Environmental Protection Agency has been conducting programmatic "economic analyses," also known as Regulatory Impact Analyses (RIAs), to assess the economic effects of its regulatory efforts. This important new volume explains the purpose of these analyses, along with their design, execution, conclusions, and their ultimate impact on environmental rules. Morgenstern, formerly director of EPA's Office of Policy Analysis, has assembled twelve original case studies of RIAs performed over the past decade. The contributors, most of whom actually worked on these RIAs, provide detailed examination of why and how they were performed. They critique the nature, amount, and quality of data used by the EPA in their benefit-cost and cost-effectiveness analyses as well as the subsequent utilization of that data in decisionmaking. The authors illustrate how the analyses take into account difficult issues such as discounting, risk, nonmonetized benefits and costs, and equity.

Morgenstern provides historical context and the legal framework for requiring and conducting EAs, including the basic procedure outlined by the Clinton administration in 1996. He synthesizes the studies into thoughtful general conclusions, drawing important lessons that will improve future analyses.

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